A formalization of one of the main claims of “FTO Obesity Variant Circuitry and Adipocyte Browning in Humans” by Claussnitzer et al. 20151

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چکیده

Claussnitzer et al. claimed in previous work that a regulatory element within the first intron of FTO affects IRX3 and IRX5 expression during early adipogenesis. We present here formalization claim, stating all things class “early human adipogenesis” are context thing “regulatory FTO” generally have relation type “affects” to “expression genes IRX5” same context.

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Commentary: FTO obesity variant circuitry and adipocyte browning in humans

BACKGROUND Genomewide association studies can be used to identify disease-relevant genomic regions, but interpretation of the data is challenging. The FTO region harbors the strongest genetic association with obesity, yet the mechanistic basis of this association remains elusive. METHODS We examined epigenomic data, allelic activity, motif conservation, regulator expression, and gene coexpres...

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FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

The authors’ affiliations are listed in the Appendix. Address reprint requests to Dr. Claussnitzer at the Gerontology Division, Beth Israel Deaconess Medical Center and Hebrew SeniorLife, Harvard Medical School, 1200 Centre St., Boston, MA 02215, or at melina@ broadinstitute . org; or to Dr. Kellis at the Computer Science and Artificial Intelligence Laboratory, MIT, 32 Vassar St., Cambridge, MA...

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ژورنال

عنوان ژورنال: Data science

سال: 2022

ISSN: ['2580-829X']

DOI: https://doi.org/10.3233/ds-210038